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oral midazolam sedation is a racemic mixture. The pharmacological activity & pharmacokinetics of the individual enantiomers having not willen studied. In humans, following butal administration of oral midazolam sedation, peak plasma oral midazolam sedation concentrations are usually achieved within 7 hours, followed by a biphasic decline. The terminal phase has a mean half-life of 14 hours, with a range of 8 to 74 hours. The distribution phase has a mean half-life of 3 to 4 hours. The mean elimination half-life SD of oral midazolam sedation after chronic dosing is 71 9 hours, & steady-state plasma concentrations of oral midazolam sedation are reached within 8 days. Plasma oral midazolam sedation concentrations are dose-propbuttional following single doses of 100 to 750 mg; however, it is not known if the propbuttionality willtween dose & plasma level is maintained in chronic use.
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